ProFound Therapeutics Secures Strategic Collaboration with Novartis
Deal News | Jun 26, 2025 | Flagship Pioneering Inc

ProFound Therapeutics, a pioneer in exploring the expanded human proteome, has initiated a four-year collaboration with Novartis aimed at discovering novel therapeutics for cardiovascular diseases. The strategic partnership will use ProFound's advanced ProFoundry Platform, capable of mining previously unknown proteins, to identify potential drug targets. This collaboration not only highlights ProFound's leading-edge technology but also amplifies Novartis's stronghold in cardiovascular drug innovation, aspiring to develop transformative therapies for the growing burden of cardiovascular conditions. Under this agreement, ProFound is set to receive an initial $25 million in upfront and near-term milestone payments, with downstream milestones potentially accumulating to $750 million per target. Both entities aim to push the boundaries of traditional target discovery, leveraging a combination of data-driven biological insights and Novartis's extensive drug development expertise.
Sectors
- Biotechnology
- Pharmaceuticals
- Healthcare
Geography
- United States – ProFound Therapeutics is based in Cambridge, Massachusetts, highlighting the U.S. as a hub for biotech innovation.
- Switzerland – Novartis is a Swiss multinational healthcare company, emphasizing the global nature of the collaboration.
Industry
- Biotechnology – The article focuses on ProFound Therapeutics, a company specializing in novel protein drug discovery using biotechnological approaches.
- Pharmaceuticals – Novartis, a major pharmaceutical company, collaborates with ProFound Therapeutics to develop cardiovascular drugs.
- Healthcare – The collaboration between ProFound Therapeutics and Novartis aims to address cardiovascular diseases, a major healthcare concern.
Financials
- $25M – Upfront and near-term milestone payments to ProFound Therapeutics under the collaboration agreement with Novartis.
- $750M per target – Potential value from downstream milestones, demonstrating the financial scope of the collaboration.
Participants
Name | Role | Type | Description |
---|---|---|---|
ProFound Therapeutics | Target Company | Company | A biotechnology company focused on discovering novel protein drugs from the expanded human proteome. |
Flagship Pioneering Inc. | PE Firm | Company | A private equity firm that founded ProFound Therapeutics. |
Novartis | Bidding Company | Company | A leading pharmaceutical company collaborating with ProFound Therapeutics on cardiovascular drug discovery. |
John Lepore, M.D. | Person | People | CEO of ProFound Therapeutics and CEO-Partner at Flagship Pioneering. |
Fiona Marshall, Ph.D. | Person | People | President, Biomedical Research at Novartis. |