Matchpoint Unveils $1 Billion Agreement with Novartis
Deal News | Jul 24, 2025 | Ropes & Gray

Ropes & Gray has successfully advised Matchpoint Therapeutics in finalizing an exclusive option and license agreement with pharmaceutical giant Novartis. Announced on July 24, this significant deal focuses on the development and commercialization of oral covalent inhibitors, which target specific transcription factors linked to a variety of inflammatory diseases. Matchpoint will utilize its proprietary Advanced Covalent Exploration platform to advance its preclinical program to development candidate selection. In exchange, Matchpoint will benefit from an upfront payment and research funding of up to $60 million from Novartis. Should Novartis proceed to exclusively license the program, it will gain global rights to any resulting products, while Matchpoint stands to earn up to $1 billion through various milestones and royalties. The advisory team from Ropes & Gray, led by key partners in life sciences licensing, tax, and litigation, played a crucial role in structuring this agreement.
Sectors
- Pharmaceuticals
- Biotechnology
- Legal Advisory
Geography
- United States – Matchpoint Therapeutics and the advising firm Ropes & Gray are based in the United States.
- Switzerland – Novartis is a Swiss multinational pharmaceutical company, making Switzerland relevant to this transaction.
Industry
- Pharmaceuticals – The article discusses a licensing and development agreement involving pharmaceuticals, particularly focused on treatments for inflammatory diseases.
- Biotechnology – The deal involves biotechnology, as it centers on the development of oral covalent inhibitors using advanced molecular platforms.
- Legal Advisory – Ropes & Gray provided legal services for this transaction, highlighting the role of legal advisories in structuring complex biopharmaceutical deals.
Financials
- $1 billion – Total potential payments under the agreement between Matchpoint and Novartis, including milestones.
- $60 million – Upfront payment and research funding provided by Novartis to Matchpoint.
Participants
| Name | Role | Type | Description |
|---|---|---|---|
| Matchpoint Therapeutics | Target Company | Companies | Biopharmaceutical company collaborating with Novartis on drug development. |
| Novartis | Bidding Company | Companies | Swiss multinational pharmaceutical company entering into a $1 billion option and license agreement with Matchpoint. |
| Ropes & Gray | Legal Advisor | Companies | Law firm advising Matchpoint on their agreement with Novartis. |
| David McIntosh | Lead Partner | People | Life sciences licensing partner at Ropes & Gray who led the advisory team. |