Alpheus Medical Propels Glioblastoma Therapy With $52M Funding Boost

Deal News | May 16, 2025 | HealthQuest Capital Management

Alpheus Medical, a clinical-stage oncology company, has successfully closed a $52 million Series B funding round to advance its sonodynamic therapy (SDT) for treating glioblastoma, an aggressive brain cancer. The financing was led by HealthQuest Capital and Samsara BioCapital, with contributions from existing investors such as OrbiMed and Action Potential Venture Capital. Key involvement also came from nonprofit venture arms like the Brain Tumor Investment Fund and Sontag Innovation Fund. The funding will finance a Phase 2B randomized controlled trial to evaluate SDT, which leverages Low-Intensity Diffuse Ultrasound combined with oral 5-aminolevulinic acid for cancer cell targeting. The non-invasive treatment is promising, potentially setting a new standard of care. HealthQuest Capital is committed to cutting-edge healthcare advances, while Alpheus focuses on non-invasive solutions for solid tumors.

Sectors

  • Biotechnology
  • Healthcare Investment
  • Oncology

Geography

  • United States – Alpheus Medical is based in Chanhassen, Minnesota, and the investors are primarily U.S.-based healthcare and biotech firms.

Industry

  • Biotechnology – Alpheus Medical is pioneering sonodynamic therapy, an innovative biotechnology for treating glioblastoma.
  • Healthcare Investment – HealthQuest Capital, Samsara BioCapital, and other investors focus on transformative healthcare innovations.
  • Oncology – The article discusses Alpheus Medical's advancements in cancer treatment, specifically targeting glioblastoma.

Financials

  • $52 million – The amount raised by Alpheus Medical in its Series B financing round.

Participants

NameRoleTypeDescription
Alpheus Medical, Inc.Target companyCompanyPrivate oncology company developing non-invasive sonodynamic therapy for cancer treatment.
HealthQuest CapitalLead investorCompanyHealthcare-focused private asset firm providing capital to transformative healthcare companies.
Samsara BioCapitalLead investorCompanyBiotech investment firm focusing on innovative therapies with significant patient impact.
OrbiMedInvestorCompanyExisting investor in Alpheus Medical, a well-known healthcare investment firm.
Action Potential Venture CapitalInvestorCompanyVenture capital firm investing in transformational health technologies.
BrightEdgeInvestorCompanyImpact investment arm of the American Cancer Society, participating in Alpheus' funding round.
Brain Tumor Investment FundInvestorCompanySubsidiary of the National Brain Tumor Society focused on funding brain tumor treatments.
Sontag Innovation FundInvestorCompanySubsidiary of The Sontag Foundation supporting innovation in medical therapies.